• By Springer   -   Jul 25, 2021

    A COMPREHENSIVE ANALYSIS OF TUMOR MICROENVIRONMENT-RELATED GENES IN COLON CANCER

    Abstract Background The development and progression of colon cancer are significantly affected by the tumor microenvironment, which...

    Genes, Cancer, Gene, Immunity
  • By Springer   -   Jul 25, 2021

    CIRC 03955 PROMOTES PANCREATIC CANCER TUMORIGENESIS AND WARBURG EFFECT BY TARGETING THE MIR-3662/HIF-1Α AXIS

    Abstract Objectives Former studies found that circRNAs play an important part in the occurrence of a variety of malignant biological...

    Biology, Clinical, Bioinformatic, Bioinformatics, Cancer, Tissue, Biologic, Biological
  • By Springer   -   Jul 25, 2021

    PROPOFOL INHIBITED GASTRIC CANCER PROLIFERATION VIA THE HSA-MIR-328-3P/STAT3 PATHWAY

    Abstract Purpose The aim of the present study was to elucidate the functional role of hsa-miR-328-3p/STAT3 pathway in the effects of...

    Bioinformatics, Bioinformatic, Cancer
  • By Springer   -   Jul 25, 2021

    MICRORNA-17-5P PROMOTES CARDIAC HYPERTROPHY BY TARGETING MFN2 TO INHIBIT AUTOPHAGY

    Abstract Pathological cardiac hypertrophy is the leading cause of heart failure, and miRNAs have been recognized as key factors in...

    Protein
  • By Springer   -   Jul 25, 2021

    MIR-33-3P REGULATES PC12 CELL PROLIFERATION AND DIFFERENTIATION IN VITRO BY TARGETING SLC29A1

    Abstract MicroRNA-33-3p has been widely investigated for its roles in lipid metabolism and mitochondrial function; however, there are...

    Neurology
  • By Springer   -   Jul 25, 2021

    MIR-33A-5P SUPPRESSES OX-LDL-STIMULATED CALCIFICATION OF VASCULAR SMOOTH MUSCLE CELLS BY TARGETING METTL3

    Abstract Oxidized low-density lipoprotein accumulation in the vascular wall plays a pivotal role in the development of atherosclerosis...

    Genes, Gene
  • By Springer   -   Jul 25, 2021

    AUTOMATED PLANT SPECIES IDENTIFICATION USING LEAF SHAPE-BASED CLASSIFICATION TECHNIQUES: A CASE STUDY ON IRANIAN MAPLES

    Abstract Foliar characteristics, especially the overall leaf shape, are useful features for the taxonomic identification of plants....

    AIDS, Computers, Applied, Plants
  • By Springer   -   Jul 25, 2021

    AN INSIGHT INTO THE INHIBITORY MECHANISM OF PHYTOCHEMICALS AND FDA-APPROVED DRUGS ON THE ACE2-SPIKE COMPLEX OF SARS-COV-2 USING COMPUTATIONAL METHODS

    Abstract The S-glycoprotein of the SARS-CoV-2 forms a complex with the human transmembrane protein angiotensin-converting enzyme 2...

    Protein, Medicine, Plants, Drugs, Computers, Drug, Enzymes
  • By Springer   -   Jul 25, 2021

    RECENT ADVANCES IN THE TECHNOLOGY OF CHAPATTI: AN INDIAN TRADITIONAL UNLEAVENED FLATBREAD

    Abstract Chapatti is a flattened circular flatbread also known as roti, poli, safari, and phulka, usually baked on a hot iron griddle....

    Food, Protein
  • By Springer   -   Jul 25, 2021

    DESIGN AND SYNTHESIS OF A NOVEL ANTIMICROBIAL PEPTIDE TARGETING Β-CATENIN IN HUMAN BREAST CANCER CELL LINES

    Abstract Antimicrobial peptides which play a vital role in an innate immune defense mechanism of various organisms can be regarded...

    Therapies, Protein, Immunity, Cancer, Chemicals, Therapeutics, DNA, Chemical
  • By Springer   -   Jul 25, 2021

    UNCOVERING ANTIMICROBIAL PEPTIDE FROM ZOPHOBAS ATRATUS USING TRANSCRIPTOME ANALYSIS

    Abstract Zophobas atratus which is also referred as giant meal worm, belongs to the largest darkling beetle family. The rich protein...

    Protein, RNA, Therapeutics, Virus, Feed, Immunity
  • By Springer   -   Jul 25, 2021

    PULSE DERIVED BIOACTIVE PEPTIDES AS NOVEL NUTRACEUTICALS: A REVIEW

    Abstract Bioactive peptides are short peptide fragments formed by amino acids joined by peptide bonds, can employ health enhancing...

    Industrial, Pharmaceuticals, General, Health, Protein, Food, Human health, Amino acids, Enzymes, Pharmaceutical, Research
  • By Springer   -   Jul 25, 2021

    LINEAR AND BRANCHED FORMS OF SHORT ANTIMICROBIAL PEPTIDE-IRK INHIBIT GROWTH OF MULTI DRUG RESISTANT STAPHYLOCOCCUS AUREUS ISOLATES FROM MASTITIC COW MILK

    Abstract Antimicrobial peptides offer a novel alternative to present day antibiotics which are becoming ineffective due to development...

    Clinical, Drug, Antibiotics, Drugs, Microbes
  • By Springer   -   Jul 25, 2021

    EXPLORING ONCHOCERCA VOLVULUS CYSTEINE PROTEASE INHIBITOR FOR MULTI-EPITOPE SUBUNIT VACCINE AGAINST ONCHOCERCIASIS: AN IMMUNOINFORMATICS APPROACH

    Abstract Onchocerciasis, caused by Onchocerca volvulus , affects more than 37 million people worldwide. Despite the progress achieved...

    Cellular, Drug, Drugs, Immunity, Computers, Vaccines, Vaccine
  • By Springer   -   Jul 25, 2021

    IN SILICO IDENTIFICATION OF MULTI-TARGET ANTI-SARS-COV-2 PEPTIDES FROM QUINOA SEED PROTEINS

    Abstract Peptides are promising antagonists against severe acute respiratory syndrome coronavirus type 2. To expedite drug discovery,...

    Discovery, Computers, Protein, Drugs, Drug
  • By Springer   -   Jul 25, 2021

    RECOMBINANT EXPRESSION OF A PLANT-DERIVED DIMERIC ANTIFUNGAL PEPTIDE JOINED BY A FLEXIBLE LINKER IN ESCHERICHIA COLI AND EVALUATION OF ITS BIOLOGICAL ACTIVITY IN VITRO

    Abstract DiSkh-AMP1, a novel dimeric antifungal peptide contained 65 amino acid residues was recombinant produced by a flexible linker...

    Biological, Gene, Biologic, Genes, Plants, Biology
  • By Springer   -   Jul 25, 2021

    INHIBITORY POTENTIAL OF A DESIGNED PEPTIDE INHIBITOR BASED ON ZYMOGEN STRUCTURE OF TRYPSIN FROM SPODOPTERA FRUGIPERDA: IN SILICO INSIGHTS

    Abstract Spodoptera frugiperda is an invasive pest in agriculture. It can potentially damage yield resulting severe crop losses and...

    Amino acids, Energy, Chemicals, Chemical, Enzymes, Agricultural, Environment, Agriculture
  • By Springer   -   Jul 25, 2021

    PROTEIN COMPOSITION AND BIOMEDICAL POTENTIAL OF THE SKIN SECRETION OF HYLARANA ERYTHRAEA FROM LANGKAWI ARCHIPELAGO, KEDAH, PENINSULAR MALAYSIA

    Abstract The skin secretion of amphibians is known for its high content of bioactive compounds. These bioactive compounds are essential...

    Biomedical, Industrial, Protein, BioMedical, Enzymes
  • By Springer   -   Jul 25, 2021

    AN IN SILICO BASED APPROACH TOWARDS THE CHARACTERIZATION WITH FEATURE IDENTIFICATION AND ANALOGY MODELING OF HUMAN OSTEOCLAST PROTEIN

    Abstract The osteoclast is a kind of bone cell that splits down the bone tissue. The osteoclast is responsible for bone disease. So,...

    Drug, Tissue, Drugs, Protein
  • By Springer   -   Jul 25, 2021

    PREDICTION OF EPITOPE BASED PEPTIDES FOR VACCINE DEVELOPMENT FROM COMPLETE PROTEOME OF NOVEL CORONA VIRUS USING IMMUNOINFORMATICS

    Abstract COVID-19 is an infectious disease caused by a newly discovered corona virus SARS-COV-2. It is the most dangerous epidemic...

    Therapeutics, Vaccines, Protein, Vaccine, Virus, Chemical, Chemicals, Computers