• Optimization of culture conditions for human bone marrow‐derived mesenchymal stromal cell expansion in macrocarrier‐based Tide Motion system

    3 days ago - By Wiley

    Successful scaling up of mammalian cell cultures in a commercial setting requires the potential optimization of various parameters. Here the impact of seeding density and media type on the expansion of mesenchymal stromal cells cultured in BioNOC II macrocarriers is analyzed. Successful expansion of MSCs from a low seeding density in both serum and serum‐free media is demonstrated, indicating the feasibility of utilizing BioNOC II microcarrier‐based tide motion system as a platform for high capacity manufacturing of MSCs.
    Background
    With high cell doses required for mesenchymal stromal...
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