• A New Framework for Discovering Protein Complex and Disease Association via Mining Multiple Databases

    1 month ago - By Springer

    Abstract
    One important challenge in the post-genomic era is to explore disease mechanisms by efficiently integrating different types of biological data. In fact, a single disease is usually caused through multiple genes products such as protein complexes rather than single gene. Therefore, it is meaningful for us to discover protein communities from the protein-protein interaction network and use them for inferring disease-disease associations. In this article, we propose a new framework including protein-protein networks, disease-gene associations and disease-complex pairs to cluster...
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