• NITUMID: Nonnegative Matrix Factorization-based Immune-TUmor MIcroenvironment Deconvolution

    8 days ago - By Oxford Journals

    AbstractMotivationA number of computational methods have been proposed recently to profile tumor microenvironment from bulk RNA data, and they have proved useful for understanding microenvironment differences among therapeutic response groups. However, these methods are not able to account for tumor proportion nor variable mRNA levels across cell types.ResultsIn this article, we propose a Non-negative Matrix Factorization-based Immune-TUmor MIcroenvironment Deconvolution framework for tumor microenvironment profiling that addresses these limitations. It is designed to provide robust...
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