• Novel algorithms for efficient subsequence searching and mapping in nanopore raw signals towards targeted sequencing

    8 days ago - By Oxford Journals

    AbstractMotivationGenome diagnostics have gradually become a prevailing routine for human healthcare. With the advances in understanding the causal genes for many human diseases, targeted sequencing provides a rapid, cost-efficient and focused option for clinical applications, such as SNP detection and haplotype classification, in a specific genomic region. Although nanopore sequencing offers a perfect tool for targeted sequencing because of its mobility, PCR-freeness, and long read properties, it poses a challenging computational problem of how to efficiently and accurately search and map...
    Read more ...